Fine Chemicals

Custom Synthesis

Novel promising fluorochemicals developed in your laboratory from the reagents listed below can be efficiently developed and synthesized in bulk by DAIKIN Industries; utilizing its industrial fluorination technologies.

Intermediates

DAIKIN produces and offers a wide range of intermediates. The selection below provides a first impression of our product range and capabilities.
If you are looking for a fluorinated compound not mentioned in the list, please contact us.

IntermediatesDetails

Chemical name	Chemical formula	CAS NO	TSCA
1H,1H-pentafluoropropanol (5FP)	CF3CF2CH2OH	422-05-9	Y
2-(perfluorobutyl)ethanol (C4 Alcohol)	F(CF2)4CH2CH2OH	2043-47-2	Y
2-(perfluorohexyl)ethanol (C6 Alcohol)	F(CF2)6CH2CH2OH	647-42-7	Y
1H,1H,3H-tetrafluoropropanol	CHF2CF2CH2OH	76-37-9	Y
1H,1H,5H-octafluoropentanol	H(CF2)4CH2OH	355-80-6	Y
1H,1H,7H-dodecafluoroheptanol	H(CF2)6CH2OH	335-99-9	Y
2H-hexafluoro-2-propanol (HFIP)	(CF3)2CHOH	920-66-1	Y
(perfluorohexyl)ethylene (C6 Olefin)	F(CF2)6CH=CH2	25291-17-2	Y
perfluorohexyl iodide (C6 Telomer)	F(CF2)6I	355-43-1	Y
2-(perfluorohexyl)ethyl iodide	F(CF2)6CH2CH2I	2043-57-4	Y
2-(perfluorohexyl)ethyl methacrylate (C6 SFMA Monomer)	F(CF2)6CH2CH2OCOC(CH3)=CH2	2144-53-8	Y
2-(perfluorohexyl)ethyl acrylate (C6 SFA Monomer)	F(CF2)6CH2CH2OCOCH=CH2	17527-29-6	Y
hexafluoroisopropyl methyl ether	(CF3)2CHOCH3	13171-18-1	N
2,2-bis(3,4-anhydrodicarboxyphenyl)hexafluoropropane (6FDA)	C19H6F6O6	1107-00-2	Y

Fluorination Technology

Beyond fluorinated intermediates, DAIKIN also provides a series of fluorinating agents as well as custom synthesis of various fluorochemicals.
DAIKIN is unique in offering iodine pentafluoride, which has rarely been used in fluorination reactions due to the difficulty of controlling reactivity. We have commercialized this technology and are able to offer this low cost, highly selective process to manufacture a variety of organic compounds.

Fluorinating reagents

Electrophilic fluorinating reagent

F-31Details

Electrophilic fluorinating reagent with the most effective fluorine content in its class (available in bulk)

Structure and properties

Chemical Name	N,N'-Difluoro-2,2'-bipyridinium bis(tetrafluoroborate)
Mol Formula	C10H8F10N2B2
Mol Weight	367.79
Appearance	White Crystal
Melting Point	166-168°C (with decomp.)
Solubility	Acetonitrile 4.7 mg/ml (25°C)
Effective F-Content	103g/kg (two F+/Mol Weight)

Characteristics

• High Effective Fluorine-Content: 103g/kg (Selectfluor: 53.6g/kg)
• Easy to handle; a glass reactor can be used.
• Cost effective fluorinating agent.
• Easy to remove another product, 2,2'-Bipyridinium bis(tetrafluoroborate) form the fluorination products, as it dissolves in diluted hydrochloric acid.
• Wide variety of application in pharmaceutical and agricultural industries, etc.
• Perfect Recycle System.

Nucleophilic Fluorinating reagent

F-81 / F-82Details

Nucleophilic Fluorinating reagent

Structure and properties

Chemical Name	1,1,2,3,3,3-Hexafluoro-1-diethylamino-propane
Chemical Formula	C7H11F6N
Molecular Weight	223.16
Appearance	colorless transparent liquid
Boiling Point	56°C / 58mmHg
Specific Gravity	1.23
CAS No.	309-88-6

 

Chemical Name	Triethylamine trishydrofluorides
Chemical Formula	C6H18F3N
Molecular Weight	161.21
Appearance	colorless liquid
Boiling Point	70°C / 15mmHg
Specific Gravity	0.989
CAS No.	73602-61-6

Characteristics

• F-81 is a nucleophilic fluorinating reagent with similar reactivity as diethylaminosulfur trifluoride (DAST). F-81 can substitute the hydroxyl group with fluorine under mild conditions.
• F-81 is a source of HF that can be handled much more easily than anhydrous HF, and is a liquid with a high boiling point.
• F-81 and F-82 can both be supplied in bulk.

Direct Fluorination using Elemental Fluorine

This is one of the lowest-cost fluorination processes. DAIKIN Industries has the technology for controlling the extreme reactivity of elemental fluorine. F2 can be an industrial agent for relatively simple compounds that have a clearly identified reactive site.

Fluorination using IF₅/Et₃N·3HF Complex

The IF₅/Et₃N·₃HF complex is a unique fluorinating reagent which can fluorinate both electrophilic and nucleophilic sites. DAIKIN Industries has commercialized this unique technology and is now able to offer this low cost, highly selective process to manufacture a variety of organic compounds.

IF₅/Et₃N·3HFDetails

Iodine pentafluoride (IF₅) has been rarely used in the fluorination of ordinary organic compounds until recently because of the difficulty in controlling its reactivity. However, Hokkaido University's Professor Yoneda discovered that the use of IF₅ in combination with Et₃N·3HF salt significantly improves the reaction selectivity and the process as a low-cost and generally applicable industrial fluorination technology, and is using it in the industrial synthesis of a variety of fluorine-containing organic materials.
An extremely unique aspect of the fluorination using IF₅/Et₃N·3HF salt is that the fluorinating reaction of organic compounds occurs at both nucleophilic and electrophilic sites as illustrated in the scheme below.

Fluorination using Sulfur tetrafluoride SF4

DAIKIN Industries is committed to manufacturing compounds using Sulfur tetrafluoride on a commercial scale. SF4 is a versatile reagent used to convert a carbonyl into a difluoromethyl group or to obtain a trifluoromethyl from a carboxylic acid.

SF4Details

Sulfur tetrafluoride can be used to efficiently fluorinate hydroxyl-, carbonyl and ester groups. DAIKIN Industries is committed to manufacturing compounds using Sulfur tetrafluoride on commercial scale. SF4 is a versatile reagent used to convert a carbonyl into a difluoromethyl group or to obtain a trifluoromethyl from a carboxylic acid, see scheme below.

Fluorinated Building Blocks

A wide range of building blocks can be derived from DAIKIN Industries' raw materials (tetrafluoroethylene, hexafluoropropene, hexafluoroacetone, tetrafluorooxetane and perfluoroalkyliodides).